Supplemental Figure 4:
Detailed version of the clustered mouse microarray experiments shown in Figure 4: Changes in mRNA levels in heat shocked wild type and HSF1-/- mouse fibroblasts.
The expression changes in both cell types are shown for A) homologs of a subset of human genes that were HSF1-bound and induced, B) homologs that were bound by HSF1 but not heat induced, and C) homologs that were induced but not bound by HSF1 in the human system. The mouse microarray data was also analyzed by clustering; these results show D) genes induced by heat in wild type but not HSF1-/- fibroblasts, E) genes induced in HSF1-/- fibroblasts, and F) genes induced similarly in wild type and HSF1 -/- fibroblasts. Panel G) shows the average expression for spots containing repetitive elements according to RepeatMasker and the standard error.
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