Figure 3: Identification of co-regulated genes that correlate with patient survival.
The Cox survival statistic was calculated for every gene using the 20 GBMs for which we could obtain survival data. Genes correlating with poorer prognosis received positive Cox scores while genes correlating with better prognosis received negative Cox scores. A moving average (window size: 71 elements) of these scores was plotted adjacent to the gene expression map from Fig. 1B. A permutation-based bootstrapping algorithm was used to calculate moving average scores that were significant at p<0.01 and these are indicated by vertical lines. Genes whose Cox statistics fall outside of these lines are significantly associated with survival. Biological themes of the genes in the various clusters are shown as in Fig 1B.