Figure 4: Expression of survival-associated genes stratifies GBMs into two clinically-distinct subgroups.
(A) Expanded view of the survival-associated gene expression signature identified in Figure 3 among the 20 GBMs with survival data. The tumors are classified as belonging to Group I (orange) or Group II (blue) based on the array dendrogram. Genes marked with asterisks were among the 500 genes with the top "intrinsic" scores (see methods). (B) Kaplan-Meier analysis of the two subgroups indicates that they have significantly different median survival times.