Gene Expression Programs in Response to Hypoxia

Gene expression programs in response to hypoxia; cell type specificity and prognostic significance in human cancers

Jen-Tsan Chi*, Zhen Wang*, Dimitry S.A. Nuyten, Edwin H. Rodriguez, Marci E. Schaner, Ali Salim, Yun Wang, Gunnar B. Kristensen, Åslaug Helland, Anne-Lise Børresen-Dale, Amato Giaccia, Michael T. Longaker, Trevor Hastie, George P. Yang, Marc J. van de Vijver, and Patrick O. Brown

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Figure 1: Overview of the Genomic Responses to Hypoxia.

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Figure 2: Cell Type-Specific Hypoxia Response.

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Figure 3: Elevated HIF-1a in RPTECs and Its Role in RPTEC Hypoxia Response.

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Figure 4: The Analysis of Hypoxia Response in Human Cancers.

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Figure 5: Quantitative Analyses of the Prognostic Significance of the Hypoxia Response Signature.

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Table 1: Epithelial Hypoxia-Induced, Wound Signature, and Clinical Risk Factors: Survival (Cox Regression).

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Table 2: Epithelial Hypoxia-Induced, Wound Signature, and Clinical Risk Factors: Metastasis as First Event (Cox Regression).

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